Herbert I Hurwitz Selected Research

Therapeutics

1/2022	Assessment of Capecitabine and Bevacizumab With or Without Atezolizumab for the Treatment of Refractory Metastatic Colorectal Cancer: A Randomized Clinical Trial.
6/2020	Bevacizumab (Avastin®) in cancer treatment: A review of 15 years of clinical experience and future outlook.
1/2020	Predictive Blood-Based Biomarkers in Patients with Epithelial Ovarian Cancer Treated with Carboplatin and Paclitaxel with or without Bevacizumab: Results from GOG-0218.
1/2020	Disease Monitoring Using Post-induction Circulating Tumor DNA Analysis Following First-Line Therapy in Patients with Metastatic Colorectal Cancer.
11/2019	A phase Ib study of capecitabine and ziv-aflibercept followed by a phase II single-arm expansion cohort in chemotherapy refractory metastatic colorectal cancer.
12/2015	Randomized, Double-Blind, Phase II Study of Ruxolitinib or Placebo in Combination With Capecitabine in Patients With Metastatic Pancreatic Cancer for Whom Therapy With Gemcitabine Has Failed.
8/2015	Direct Evidence of Target Inhibition with Anti-VEGF, EGFR, and mTOR Therapies in a Clinical Model of Wound Healing.
11/2014	The search for biomarkers to direct antiangiogenic treatment in epithelial ovarian cancer.
10/2014	A phase I clinical trial of navitoclax, a targeted high-affinity Bcl-2 family inhibitor, in combination with gemcitabine in patients with solid tumors.
8/2014	A phase Ib study of combined VEGFR and mTOR inhibition with vatalanib and everolimus in patients with advanced renal cell carcinoma.

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Herbert I Hurwitz Research Topics

Disease

67	Neoplasms (Cancer) 04/2022 - 06/2003
51	Colorectal Neoplasms (Colorectal Cancer) 04/2022 - 01/2003
9	Disease Progression 01/2022 - 01/2003
8	Neoplasm Metastasis (Metastasis) 01/2022 - 06/2003
8	Pancreatic Neoplasms (Pancreatic Cancer) 01/2019 - 01/2002
8	Adenocarcinoma 05/2014 - 01/2002
5	Wounds and Injuries (Trauma) 08/2015 - 02/2003
5	Carcinoma (Carcinomatosis) 03/2008 - 07/2005
4	Neutropenia 01/2019 - 06/2013
4	Fatigue 01/2018 - 12/2009
4	Diarrhea 10/2014 - 12/2009
4	Rectal Neoplasms (Rectal Cancer) 06/2007 - 03/2004
3	Renal Cell Carcinoma (Grawitz Tumor) 01/2022 - 08/2014
3	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 06/2020 - 01/2013
3	Ovarian Neoplasms (Ovarian Cancer) 06/2020 - 04/2010
3	Thrombocytopenia (Thrombopenia) 01/2017 - 07/2012
3	Anemia 12/2015 - 01/2014
3	Colonic Neoplasms (Colon Cancer) 03/2013 - 06/2003
3	Hemorrhage 01/2013 - 05/2005
3	Hypertension (High Blood Pressure) 01/2013 - 05/2005
3	Esophageal Neoplasms (Esophageal Cancer) 03/2008 - 03/2007
2	Breast Neoplasms (Breast Cancer) 06/2020 - 08/2005
2	Ovarian Epithelial Carcinoma 01/2020 - 11/2014
2	Nausea 01/2018 - 10/2014
2	Inflammation (Inflammations) 01/2017 - 12/2015
2	Esophagitis 01/2017 - 03/2007
2	Gastrointestinal Stromal Tumors (Gastrointestinal Stromal Tumor) 01/2015 - 06/2012
2	Vomiting 10/2014 - 12/2009
2	Mucositis 07/2012 - 02/2011
2	Exanthema (Rash) 07/2012 - 02/2011
2	Cholangiocarcinoma 11/2011 - 01/2009
2	Pathologic Complete Response 03/2008 - 03/2007
2	Squamous Cell Carcinoma (Epidermoid Carcinoma) 03/2008 - 03/2007
1	Uterine Cervical Neoplasms (Cancer of the Cervix) 06/2020
1	Hepatocellular Carcinoma (Hepatoma) 06/2020
1	Glioblastoma (Glioblastoma Multiforme) 06/2020
1	Kidney Neoplasms (Kidney Cancer) 01/2020
1	Constipation 01/2018
1	Sarcoma (Soft Tissue Sarcoma) 01/2018
1	Back Pain (Backache) 01/2018

Drug/Important Bio-Agent (IBA)

54	Bevacizumab (Avastin)FDA Link 04/2022 - 01/2003
22	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 01/2022 - 01/2003
17	Biomarkers (Surrogate Marker)IBA 01/2022 - 03/2005
16	Fluorouracil (Carac)FDA LinkGeneric 01/2019 - 01/2003
15	Irinotecan (Camptosar)FDA LinkGeneric 01/2022 - 01/2004
14	Oxaliplatin (Eloxatin)FDA LinkGeneric 01/2022 - 01/2004
13	Capecitabine (Xeloda)FDA Link 01/2022 - 02/2006
10	Monoclonal AntibodiesIBA 10/2019 - 01/2003
10	Leucovorin (Folinic Acid)FDA Link 01/2019 - 01/2003
8	Everolimus FDA Link 01/2018 - 01/2011
7	Cetuximab (Erbitux)FDA Link 01/2022 - 08/2006
6	ErbB Receptors (EGF Receptor)IBA 01/2022 - 03/2005
6	Gemcitabine FDA Link 01/2019 - 12/2009
5	Messenger RNA (mRNA)IBA 03/2015 - 01/2002
4	LigandsIBA 01/2022 - 12/2005
4	Panitumumab (Vectibix)FDA Link 01/2021 - 01/2011
4	Paclitaxel (Taxol)FDA LinkGeneric 01/2020 - 03/2007
4	Proteins (Proteins, Gene)FDA Link 11/2018 - 06/2014
4	EndoglinIBA 10/2018 - 09/2012
4	Angiogenesis InhibitorsIBA 11/2014 - 07/2003
3	SteamIBA 04/2022 - 01/2019
3	Carboplatin (JM8)FDA LinkGeneric 01/2020 - 03/2007
3	Lapatinib (GW572016)FDA Link 01/2019 - 08/2005
3	carotuximabIBA 10/2018 - 09/2012
3	pazopanib FDA Link 01/2017 - 06/2009
3	Sunitinib (Sutent)FDA Link 01/2015 - 10/2007
3	Imatinib Mesylate (Gleevec)FDA Link 01/2015 - 04/2010
2	Circulating Tumor DNAIBA 04/2022 - 01/2020
2	afliberceptIBA 11/2019 - 01/2013
2	Activin Receptors (Activin Receptor)IBA 10/2019 - 01/2014
2	ProdrugsIBA 01/2017 - 06/2012
2	Phosphotransferases (Kinase)IBA 05/2015 - 08/2005
2	ParaffinIBA 03/2015 - 01/2011
2	intetumumabIBA 02/2015 - 03/2013
2	EnzymesIBA 10/2014 - 06/2013
2	Dasatinib (BMS 354825)FDA Link 04/2014 - 03/2013
2	Dihydrotachysterol (AT 10)IBA 07/2012 - 09/2011
2	lonafarnib (SCH 66336)IBA 11/2011 - 02/2011
2	eniluracilIBA 02/2006 - 03/2004
2	Carcinoembryonic AntigenIBA 06/2003 - 01/2002
1	atezolizumabIBA 01/2022
1	Blood Proteins (Serum Proteins)IBA 01/2022
1	cabozantinibIBA 01/2021
1	Interleukin-6 (Interleukin 6)IBA 01/2020
1	RNA (Ribonucleic Acid)IBA 11/2019
1	ascrinvacumabIBA 10/2019
1	regorafenibIBA 10/2019
1	Cytochrome P-450 CYP3A InhibitorsIBA 01/2019
1	Vascular Endothelial Growth Factor CIBA 11/2018
1	Angiogenic ProteinsIBA 11/2018
1	ganitumabIBA 01/2018
1	ontuxizumabIBA 01/2018

Therapy/Procedure

35	Therapeutics 01/2022 - 01/2002
32	Drug Therapy (Chemotherapy) 01/2022 - 01/2003
10	Radiotherapy 11/2011 - 03/2004
6	Chemoradiotherapy 11/2011 - 01/2002
2	Immunotherapy 06/2020 - 01/2002
2	Pancreaticoduodenectomy 05/2014 - 01/2002
2	Esophagectomy 03/2008 - 03/2007
2	Neoadjuvant Therapy 11/2007 - 01/2002